PBN1 - Molecular Introduction

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Integration of morphologic and molecular findings in neoplasms (for details, please refer to Histopathology 2008; 53(1):1-19).

Molecular definition of neoplasm and precursor lesions. Intraepithelial lesions and topographic heterogeneity.

Biological bases of neoplasm natural history.

Clonality and loss of heterozygosity (LOH) in neoplasms. Fractional allelic loss.

Genetic control of initiation and promotion. Tumor progression.

Topographic heterogeneity and tumor cell segregation. Accumulation of genetic alterations.

Molecular pathways pleiotropism and redundancy.